Molecular Profiling of Alveolar Soft Part Sarcoma 1 High resolution array CGH and gene expression profiling of alveolar soft part sarcoma
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Human Cancer Biology High-Resolution Array CGH and Gene Expression Profiling of Alveolar Soft Part Sarcoma
Purpose: Alveolar soft part sarcoma (ASPS) is a soft tissue sarcoma with poor prognosis, and little molecular evidence exists for its origin, initiation, and progression. The aim of this study was to elucidate candidate molecular pathways involved in tumor pathogenesis. Experimental Design: We employed high-throughput array comparative genomic hybridization (aCGH) and cDNA-Mediated Annealing, S...
متن کاملHigh-resolution array CGH and gene expression profiling of alveolar soft part sarcoma.
PURPOSE Alveolar soft part sarcoma (ASPS) is a soft tissue sarcoma with poor prognosis, and little molecular evidence exists for its origin, initiation, and progression. The aim of this study was to elucidate candidate molecular pathways involved in tumor pathogenesis. EXPERIMENTAL DESIGN We employed high-throughput array comparative genomic hybridization (aCGH) and cDNA-Mediated Annealing, S...
متن کاملMetastasis of alveolar soft part sarcoma of the retroperitoneum to distal phalanx of hand
Hand metastasis accounts for approximately 0.1 percent of all metastatic osseous malignancies. The lung, breast and kidney are the most common primary sources of these metastatic lesions.A rare case of retroperitoneal alveolar soft part sarcoma metastasizing to the distal phalanx of the second finger of the right hand is presented here. The patient underwent complete DIP amputation of the affec...
متن کاملگزارش یک مورد نادر بروز اولیه سارکوم آلوئولار بافت نرم با متاستاز به مخچه
Introduction: Alveolar soft part sarcoma is a malignant soft tissue tumor whose metastasis to other organs like lung and brain as a primary presented symptom is not unusual. In the literature there are many reports of metastasis to different parts of brain, but cerebellar metastasis has not been reported yet. In this case study, we discuss a rare occurrence of simultaneous metastasis to bra...
متن کاملAlveolar soft part sarcoma of lung: report of a unique case with emphasis on diagnostic utility of molecular genetic analysis for TFE3 gene rearrangement and immunohistochemistry for TFE3 antigen expression
Alveolar soft part sarcoma (ASPS) is a rare, malignant mesenchymal tumor of distinctive clinical, morphologic, ultrastructural, and cytogenetical characteristics. It typically arises in the extremities of adolescents and young adults, but has also been documented in a number of unusual sites, thus causing diagnostic confusions both clinically and morphologically. The molecular signature of ASPS...
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تاریخ انتشار 2013